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KMID : 0360319950270010069
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 1 p.69 ~ p.76
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Discrepancies between the Biochemical and Immunohistochemical Assays of the Progestrone Receptor: Correlations with Classical Prognostic Factors in Breast Carcinoma
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김대연
한세환/노동영/박인애/정준기/최국진
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Abstract
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Breast cancer specimens from 77 patients were assayed for the presence of progesterone receptors (PR) utilizing the biochemical assay (Dextran Coated Charcoal) and immunohistochemical assay (ICA). The PR status of these patients were evaluated
in
respect to age and size of the tumor, axillary lymph-node metastasis, and cell differentiation according to the each method. The number of PR positive tumor was 23 cases (29.9%) in DCC and 42 cases (54.5%) in PR-ICA. The concordance of both
assays
is
0.304. There was no correlation between PR status and the age of patients in both assays. There was increase of PR expression in smaller tumor, but that was significant in only ICA (P<0.05). The relationship between axillary lymphnode metastasis
and PR
expression was not proven by ICA but there was significant increase of PR positive ratio in lesser axillary lymph-node metastasis with DCC method (P<0.05). The relationship between TNM stage and PR expression was not proven by ICA method but
there
was
significant increase of PR positive ratio in early TNM stage with DCC method (P<0.05). The relationship between histologic grade and PR expression was not observed. In this study, the results of ICA showed higher expression rate than DCC method.
The ICA
was correlated with the size of tumor, while the DCC assay was correlated with the axillary lymph-node metastasis and stage.
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KEYWORD
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